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| Biological Age |
It may be possible to reverse a person's biological age, says new study
Researchers have found that reversal of a person's biological age or epigenetic clock is possible through the administration of growth hormone and some diabetes drugs.
During a clinical study in California, scientists found that growth hormone as well as two widely used anti-diabetic drugs - dehydroepiandrosterone (DHEA) and metformin - have been used for nearly 2.5 years by the body's epigenetic clock, DNA. Can be rejuvenated by a biochemical test based on. Methylation levels that can be used to track the aging process. The newly published study also revealed that participants' immune systems show signs of rejuvenation.
The epigenetic clock, which depends on the body's epigenome and tagged DNA, can be trailing or exceeding chronological age.
This is the first time that scientists have looked at the possibilities of reversing the human aging process. However, he warned that the findings were small because the trial was small and did not include a control group, the journal Nature reported.
"I hope I slow down the clock, but not the reverse," said geneticist Steve Horwath at the University of California, Los Angeles, who conducted the analysis.
The test was conducted to test whether growth hormone can be safely used in humans to restore tissue in the thymus gland in the lungs and between the breast. The gland is important for efficient immune function, which begins to shrink after puberty and is rapidly filled with fat.
Animal evidence and some human studies showed growth hormone-stimulated uptake of the thymus, but also promoted diabetes. Therefore, the study included two widely used anti-diabetic drugs.
The Thymus Regeneration, Immunization and Insulin Mitigation (TRIIM) trial The trial was led by Gregory Fehey, Chief Scientific Officer and Co-Defendant of InterVeni Immune in Los Angeles.
Fahy was fascinated with the thymus since 1986 when he read a study in which scientists transplanted growth-hormone-secreting cells into mice and rejuvenated their immune systems. He later treated himself with growth hormone and DHEA for a month and found some uptake of his thymus.
Investigating the effect of the drugs on the participants' epigenetic clocks occurred later as Fahy later contacted Horwath to conduct the analysis.
"Because we can follow the changes within each person, and because the impact was very strong in each of them, I'm optimistic," says Horwath, the findings were published in the journal Journal.
It should be mentioned that researchers have already begun testing metformin, an oral diabetes drug, for its ability to protect against common age-related diseases such as cancer and heart disease.
Reviving the thymus can be useful in people with underactive immune systems, including those over 70 years of age.